Prevalence of Hypervirulent BI/NAP1/027 Clostridium difficile Strains in Cali-Colombia
نویسندگان
چکیده
2053. FilmArray® Gastrointestinal (GI) Panel for Viral Acute Gastroenteritis Detection in Pediatric Patients Neena Kanwar, PhD; Jami Jackson, DO; Susan Duffy, MD; Kimberle Chapin, MD; Daniel Cohen, MD; Amy Leber, PhD; Judy a. Daly, PhD; Andrew Pavia, MD, FIDSA, FSHEA, FPIDS; Chari Larsen, MD; Tanya Baca, MD; Jeffery Bender, MD; Jennifer Dien Bard, Ph.D; Ara Festekjian, MD, MS; Kristen Holmberg, MS; Kevin Bourzac, PhD and Rangaraj Selvarangan, PhD; Children’s Mercy Hospital, Kansas City, Missouri, Rhode Island Hospital, Providence, RI, Pathology, Rhode Island, Hasbro Medical Center, Providence, Rhode Island, Pediatrics, Section of Emergency Medicine, Nationwide Children’s Hospital, Columbus, Ohio, Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, Ohio, Department of Pathology, Division of Clinical Pathology, University of Utah School of Medicine, Salt Lake City, Utah, Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, Pediatrics, University of Utah, Salt Lake City, Utah, University of Utah, Salt Lake City, Utah, Pediatrics, Children’s Hospital Los Angeles, Los Angeles, California, Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, California, Children’s Hospital Los Angeles, Los Angeles, California, BioFire Diagnostics, LLC, Salt Lake City, Utah, Children’s Mercy Hospital and Clinics, Kansas City, Missouri
منابع مشابه
Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027
Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and a major burden to healthcare services worldwide. In recent years, C. difficile strains belonging to the BI/NAP1/027 type have become highly represented among clinical isolates. These so-called 'hypervirulent' strains are associated with outbreaks of increased disease severity, higher relapse rates and an expanded ...
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Infection with Clostridium difficile is a growing concern because of the increasing prevalence and spread of nosocomial infections. Emergence of the hypervirulent 027/NAP1/BI strain is also notable. Existing diagnostic methods have low sensitivity or are time-consuming. Therefore, establishing a rapid and accurate microbiological diagnostic assay is needed. We evaluated the Xpert C. difficile a...
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In the past decade, the epidemiology and treatment of Clostridium difficile–associated diarrhea (CDAD) have significantly changed. C. difficile remains the most important cause of healthcare-associated diarrhea and is increasingly important as a community pathogen. The strains of C. difficile with hypervirulent BI-NAP1-027 and nonBI-NAP1-027 have been reported for after the use of nearly all sy...
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Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplific...
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Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed world. The main virulence factors of the bacterium are the large clostridial toxins (LCTs), TcdA and TcdB, which are largely responsible for the symptoms of the disease. Recent outbreaks of CDI have been associated with the emergence of hypervirulent strains, such as NAP1/BI/027, many strains of w...
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